TO FIX IBD,

LOOK AT THE

MICROBIOME

The gut microbiome plays a crucial role in the pathogenesis of Inflammatory Bowel Diseases (IBD i.e. Crohn’s disease, ulcerative colitis, or celiac disease), which are chronic, relapsing and remitting set of conditions characterized by an excessive inflammatory response leading to the destruction of the gastrointestinal tract and having a significant deleterious impact on a growing number of patients.
Increasing evidence suggests that mucosal lesions are generated by a dysregulated immune response against commensal microbes in the gut. Enterome is pioneering the development of innovative therapeutic approaches (drugs and diagnostics), to support a personalized medicine for microbiome-related diseases with a special focus on IBD.
NEWS, PRESS

& EVENTS

NEWS & EVENTS

CAREERS

Offre de poste – Biologiste moléculaire (CDI)

BIOLOGISTE MOLECULAIRE (H/F) Durée du poste : CDI Date de début : Dès que possible Nom du contact : Alessandra Cervino Email du contact : acervino@enterome.com >.. Read More →

Offre de poste – Bioinformaticien (CDI)

BIOINFORMATICIEN (H/F) Durée du poste : CDI Date de début : Dès que possible Nom du contact : Francesco Strozzi Email du contact : fstrozzi@enterome.com > Voir la fiche.. Read More →
2016

26Jun

Summit for Cancer Immunotherapy

Date : 26-29 June 2016 Location : Halifax (Canada) View the link.. Read More →
28Jun

JOBIM 2016 Journées Ouvertes en Biologie, Informatique et Mathématiques

Date : 28-30 June Location : Lyon (France) View the link.. Read More →
30Jun

2nd Paris Nash Symposium 2016

Date : 30 June-1 July Location : Paris (France) View the link.. Read More →
30Jun

The Barcelona debates on the human microbiome

Date : 30 June-1 July Location : Barcelona (Spain) View the link.. Read More →
MORE NEWS & EVENTS
PRESS RELEASES
2016
19May

Enterome initiates strategic expansion with the opening of US office in Cambridge, MA

Paris, France and Cambridge, MA, USA – May 19, 2016 Enterome Bioscience SA (“Enterome”), a pioneer in the development of pharmaceuticals and diagnostics based on.. Read More →
20Apr

Enterome raises €14.5 million in Series C financing round Nestlé Health Science invests alongside existing investors

Paris, France and Boston, MA – April 20 2016 ENTEROME Bioscience SA, a pioneer in the development of pharmaceuticals and diagnosticsbased on the gut microbiome,.. Read More →
18Apr

Enterome in-licenses novel compounds from Vertex Pharmaceuticals to treat microbiome-related inflammatory bowel diseases

Paris, France and Boston, MA – April 18 2016 ENTEROME Bioscience SA, a pioneer in the development of pharmaceuticals and diagnostics based on the gut.. Read More →
2015
02Oct

Georges Gemayel Appointed Non-executive Chairman of Enterome

Paris, France – 29 September 2015 Georges Gemayel Appointed Non-executive Chairman of Enterome ENTEROME Bioscience SA, a pioneer in the development of therapeutic solutions (drugs.. Read More →
MORE PRESS RELEASES
COMPANY

Enterome is a Paris-based private company with advanced technology and products in the emerging field of disease management of the human gut microbiome. Enterome has recently opened a subsidiary in Cambridge (MA).

Our company has been established in 2012 and has already raised a €17.5m in two rounds with private equity funds (Seventure, Omnes Capital, Lundbeckfond Ventures, Health for Life Capital) and strategic investors (INRA Transfert & Shire).

Enterome is developing innovative therapeutic solutions in the new and promising field of diseases associated with abnormalities of the gut microbiome and that are as diverse as Crohn’s disease, asthma, obesity, diabetes, multiple sclerosis, and some forms of cancers.

The technology developed by Enterome and its scientific founders has allowed taking microbiome science to the next level of its development through the identification of a new organ involved in the development of a series of serious disorders.

MANAGEMENT

PIERRE BELICHARD

CEO

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VP M&A and business development at Sanofi Ophthalmology, Pierre was the founder and COO of Fovea Pharmaceuticals and has been instrumental in building up the product-portfolio that became the Ophthalmology division of Sanofi (Fovea was acquired by sanofi in 2009 for €370m, less than five years after inception). Earlier, Pierre was VP Business Development at UroGene, a company sold to Pierre Fabre in 2004. In 2000, he took over the position of head of European commercial operations at Ethypharm. Prior to this, Pierre held various positions in science and business development at Fournier Pharma. Pierre is PharmD, PhD and holds a MBA from INSEAD.

MARIE-LAURE BOUTTIER

COO

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Business Development & Contract Manager at Sanofi, Marie-Laure joined Fovea Pharmaceuticals at inception as Business Development associate and has been involved in all licensing and contractual operations of the company from founding to trade sale to Sanofi. Earlier, Marie-Laure has been Business Development associate at UroGene.

RODOLPHE CLERVAL

CBO

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Before joining Enterome, Rodolphe Clerval was VP Corporate and Business Development of TcLand Expression, a molecular diagnostic company. During his tenure with TcLand Expression, he led strategic planning activities and closed several collaborations and licensing deals. Previously he was Business Development Manager at Genzyme. Prior to this he was financial analyst for the brokerage firm Natixis Bleichroeder. Earlier in his career, Rodolphe served as Research Scientist at Aventis Animal Nutrition.

JEAN-MICHEL PAILLARSE

MEDICAL DIRECTOR

 

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Jean-Michel has more than 20 years expertise in clinical development plan design from phase I to IV and writing of key regulatory documents. He has an international and wide range of experiences in various company types from biotech (Ablynx, AB Science, Diatos) to major pharmaceutical companies (Glaxo, Eli Lilly, Sanofi) and Clinical Research Organisations (Harrison Clinical Research).

CHRISTELLE DUMOUSSAUD

FINANCE & ADMINISTRATION

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Christelle joined Enterome in November 2015 with more than 20 years of experience in financial departments of various industries. Lately, she worked in the services industries for public and private companies, focused on structuring the administrative and finance department and on securing the business development. She previously served as Finance Director at Fournier/Solvay Pharma. During these years, she was in charge of cross-functional projects regarding the reorganization of the new pharmaceutical division and acted during 4 years as CFO of the Belgian subsidiary. She has started her career as business analyst for mass market groups like Sara Lee and Diageo. Christelle holds a Master in Business Management from the ISC Paris.

LAURENT CHÊNE

HEAD OF DRUG DISCOVERY

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Laurent joined Enterome in January 2015 with more than 15 years of experience in target identification and drug discovery. He obtained his PhD in Pasteur Institute, working on HIV in the F. Barre Sinoussi Lab. He next started his carrier in Industry in 2001 working in medium biotech as UroGene or Inventiva and in larger groups as Fournier, Solvay and Abbott. During these years, he was in charge of medium throughput screening platforms dedicated to genomic and transcriptomic analysis. He was also project leaders on several preclinical targets in a large range of therapeutic area as metabolic disorders, oncology, inflammatory diseases and CNS disorders.

ALESSANDRA CERVINO

HEAD OF BIOMARKER DISCOVERY

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Alessandra joined Enterome in March 2014 where she is leading the biomarker discovery and development activities. She has developed and industrialized the first full quantitative metagenomics pipeline to translate metagenomics research into diagnostics. Prior to joining Enterome she was CSO of Tcland Expression, Assistant Professor at Scripps Florida and senior research scientist at Merck & Co. She has been awarded honorary positions in US and UK academia (Research Professorship at Florida Atlantic University and Senior Lectureship at King’s College London) and is the founder to Luxia Scientific, a consulting firm specialized in advising investment funds. Alessandra holds a DPhil from the University of Oxford in Clinical Medicine and an MSc in Biometry.

DUSKO EHRLICH

SCIENTIFIC FOUNDER

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Research director at INRA, Dusko is leader the MetaGenoPolis initiative (French national Metagenomic plateform). Author or co-author of more than 350 publications in scientific journals and books, he is regularly invited in scientific symposia and is a frequent speaker in international conferences held in Europe, USA, Japan. He is coordinator of numerous international (EU, USA, Japan and China) collaborative programs, MetaHIT in particular. Dusko has active collaborations with international companies (Pfizer, Danone, BioMérieux,BGI, …)

NON-EXECUTIVE DIRECTORS

GEORGES GEMAYEL

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Georges has over 25 years of experience in the pharmaceutical industry, including management and executive positions in the US, Europe and the Middle East. He currently serves on the board of directors of US publicly-traded companies Supernus Pharmaceuticals, Inc. and Raptor Pharmaceutical Corp., and is the Chairman of the boards of OxThera AB, EpiTherapeutics ApS and Orphazyme ApS.

From 2008 to 2009, Dr Gemayel was President and Chief Executive Officer of Altus Pharmaceuticals Inc., a publicly-traded pharmaceutical company. From 2003 to 2008, he was Executive Vice President at Genzyme Corporation where he was responsible for the company’s global therapeutics, transplant, renal and biosurgery businesses. From 1998 to 2003, he held progressively senior roles at Hoffmann La-Roche and Roche Labs, most recently as Vice President, National Specialty Care, responsible for its US business for dermatology, oncology, transplantation, hepatitis and HIV.

PIERRE CASSIGNEUL

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Pierre has over 25 years’ experience in leading organizations and high-growth-potential start-ups through the development and launch of innovative tests and high-science clinical diagnostic solution. He is currently President and Chief Executive Officer at NMS Labs. Before this, he was CEO at Molecular Diagnostic LTD, President and CEO, XDX Inc. Earlier, Pierre was VP Diabetes Management, Becton Dickinson, Senior VP Business Operations, Bayer US and BU General Manager, J&J.

FELIX FRUEH

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Felix is a respected thought leader in personalized medicine with nearly twenty years of R&D, management and policy experience. He is currently CSO at Human Longevity Inc. He was also Manager in residence at Third Rock and President, Medco Research Institute at Medco Health Solutions, Inc. (now Express Scripts). Earlier, Felix was Associate Director for Genomics at FDA/CDER/Office of Clinical Pharmacology (OCP) and Research Director, Pharmacogenetics at Transgenomic.

INVESTORS

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Being one of the leading venture capital firms in Europe, Seventure manages €500m and invests since 1997 in innovative businesses with high growth potential in IT and in Life Sciences. With preferred sectors of Biotech & Pharmaceuticals, Medtech, Industrial Biotech & Cleantech, and Lifestyle Healthcare & Nutrition. Seventure is a subsidiary of Natixis.

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Lundbeckfond Ventures is an life science venture fund established in 2009 and wholly owned by the Lundbeck Foundation. On an annual basis, Lundbeckfond Ventures invests up to € 50 million. Investments are made within lifescience, focusing on pharmaceuticals and biopharmaceuticals, medtech, diagnostics and healthcare service companies.

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Omnes Capital is a major player in private equity, with a commitment to financing SMEs. With €2.1 billion in assets under management, Omnes Capital provides companies with the capital needed to finance their growth. Omnes Capital, formerly Crédit Agricole Private Equity, was a subsidiary of Crédit Agricole until March 2012 when the company was acquired by Coller Capital.

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Shire is a pharmaceutical company formed 25 years ago and focusing on developing treatments for conditions in a large range of domains like CNS, Gastrointestinal, Orphan genetic diseases, Allergy and Hematology. In 2011, the company’s revenue was USD 4.3 billion. Shire has committed initial capital funding of $50 million to establish a Strategic Investment Group. Shire co-invests via the SIG as part of a syndicate.

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Health for Life Capital supports innovative high-growth entrepreneurial ventures. Geographically, its focus is primarily in Europe, but also extends to North America and Asia. Investments will be made in the areas of healthcare, life sciences, biotechnology, medical technologies, pharmaceuticals, nutrition and in the emerging fields of microbiome and connected health.

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INRA Transfert is a project engineering company and technology transfer for food innovation, agriculture and environment that promotes and manages the INRA technology portfolio through operating agreements with industry and supports the development of young innovative companies.

PIPELINE
TECHNOLOGY
Enterome has been created in 2012 to develop products from the scientific results obtained in the gut microbiome space by the French National Institute of Agronomy Research (INRA, Paris). Dusko Ehrlich and his team have been pioneers in the measurement and modulation of gut microbiome’s role in health and diseases. This field has emerged as one of the newest and most promising field of medical sciences.
SCIENCE
20 YEARS OF HIGH LEVEL MICROBIOME SCIENCE100%
> 100 high impact factor publications100%
TECHNOLOGY

QUANTITATIVE MG

FUNCTIONAL MG

Enterome uses two different platforms :

  • A QUANTITATIVE METAGENOMICS PLATEFORM based on full sequencing and mapping of total fecal bacterial gene content that allows the characterization of a personal metagenome (metagenotype®) associated with a disease phenotype. This technology enables the identification of biomarkers and of bacteria of interest associated with the development of diseases.
  • A FUNCTIONAL METAGENOMICS PLATEFORM based on the screening of genomic or metagenomics libraries on cell based assays and on specific pathways of interest that allows the discovery and the development of news drugs and targets.
MARKET
In 2020
5600
Million $USD
600000
PATIENTS

The overall Crohn’s Disease (CD) market will increase from approximately $3.8 billion in 2011 to $5.6 billion in 2021. The specialty GI category is growing faster than any other therapeutic area (Evaluate Pharma – 2014)

In 2011, in US and EU, CD prevalence is estimated around 1 million patients, among them 500 000 patients are currently under medication for treating moderate-to-severe form of the disease. This figure will outpace 600 000 moderate-to-severe patients by 2020 (Datamonitor – 2014).

Current medical treatment of CD consists of immunosuppressive drug therapy (corticosteroids, azathioprine, methotrexate, anti-TNF monoclonal antibodies). These agents control symptoms of CD in most patients, but their withdrawal leads to disease relapse. They are also associated with serious side effects (infections, lymphoma, cancers, liver toxicity). Anti-TNF monoclonal antibodies are the most efficacious but are cost prohibitive. Moreover, each year, roughly 10% of responders to anti-TNF become refractory to treatment, most often because they become tolerized to these drugs. Future CD drugs are small molecules or biologics that antagonize proinflammatory cytokines or gut homing of lymphocytes. Yet, they have similar safety issues as the immunosuppressive agents currently in use.

PRODUCTS

The current therapeutic algorithm for CD does not take into account the site of inflammation or composition of intestinal microbiome. Moreover, dysregulated intestinal immunity and overproduction of proinflammatory cytokines are not the only components of CD pathophysiology. Intestinal microbiome is abnormal and plays an important role in the pathogenesis of CD.

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In order to prepare the next generation of IBD drugs, Enterome is leading a discovery program of novel products originating from the gut microbiome with its high throughput discovery platform. Metagenomic/genomic libraries have been developed to identify active commensal derived molecules with regulatory functions and among them, new compounds for therapeutic purpose or new targets/pathways for drug discovery programs.

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IBD110 is the first noninvasive gut microbiome biomarker surrogate marker of mucosal healing.

It has initially been identified in a 100 patient longitudinal cohort of Crohn’s disease (CD) patients and further validated in an independent international cohort of 300 CD patients.

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contact

CONTACT

ENTEROME FRANCE

ENTEROME FRANCE

Headquarters and Facilities

94/96 avenue Ledru-Rollin

75011 Paris – France

Tel : +33 (0)1 75 77 27 85

Email : info@enterome.com

ENTEROME USA

ENTEROME USA

Subsidiary

One Broadway, 14th Floor,

Cambridge MA 02142,

USA

Email : info@enterome.com

ENTEROME IS LOOKING FOR NEW TALENTS IN BIOINFORMATICS, CLINICS AND PROJECT MANAGEMENT.

Offre de poste – Biologiste moléculaire (CDI)

BIOLOGISTE MOLECULAIRE (H/F) Durée du poste : CDI Date de début : Dès que possible Nom du contact : Alessandra Cervino Email du contact : acervino@enterome.com >.. Read More →

Offre de poste – Bioinformaticien (CDI)

BIOINFORMATICIEN (H/F) Durée du poste : CDI Date de début : Dès que possible Nom du contact : Francesco Strozzi Email du contact : fstrozzi@enterome.com > Voir la fiche.. Read More →

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info@enterome.com

+33 (0)1 75 77 27 85

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