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ABSTRACT

June, 1st 2018

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EB8018, a novel FimH blocker is well tolerated in a randomized, double-blind, placebo-controlled Phase I study in healthy volunteers

EB8018 is a novel, first-in-class oral small molecule that is a minimally absorbed, gut restricted molecule that represents a non-biologic, non-steroidal, non-immunomodulatory approach for the treatment of Crohn’s Disease.  EB8018 inhibits adhesion of FimH expressed by some pro-inflammatory bacteria such as Adherent, Invasive E Coli and Klebsiella to mannosylated receptors in the gut wall, thereby reducing the generation of inflammatory cytokines.

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PROGRAM

May 29th, 2018

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MSPminer

© 2016-2018 Enterome & INRA

 

MSPminer reconstitutes Metagenomic Species Pan-genomes by binning co-abundant genes across metagenomic samples.

For further information, consult the paper published in Bioinformatics available at: https://doi.org/10.1093/bioinformatics/bty830

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