Function Description

This is a fixed term contract offer (CDD) of 12 months.

You will work within a dynamic and engaging environment in the Immuno-Oncology team under the supervision of the Team Leader of the group. You will plan and execute preclinical mouse studies and in vitro immune cell-based assays to evaluate novel therapeutic vaccine candidates. The responsibilities include, but are not limited to fluorescent, colorimetric or label-free enzymatic and binding kinetics assays, cell culture and cellular assays, qPCR, ELISA and flow cytometry.

Responsibilities

1. Perform studies in agreement with timelines and procedures. Must be able to organize work, multiple and diverse tasks, and functions.
2. Ability to work independently and as part of a team.
3. Ability to deliver and share result with other team members
4. Ability to analyze and resolve problems.
5. Organize and store laboratory data in dedicated support (ELN, Laboratory notebook) and interpreting all results.
6. Maintenance of the laboratory equipment

Tasks

1. Manage daily workflow independently and seek advice when appropriate
2. Purify immune cell subsets from patient samples, and maintain cells in primary cultures
3. Perform flow cytometry-based phenotyping and functional analysis of immune cells
4. Develop and perform co-culture cytotoxicity assays using human cancer cell lines, and primary immune cells
5. Develop and implement in vivo experiments and in vitro assay systems to support lead candidate selection and characterization
6. Perform blood collection techniques, Dosing techniques and Tissue collection
7. Analyze, interpret, organize, and report/present experimental data
8. Identify methodological problems in research protocol and implement modifications to optimize the assay and the experimental results.
9. Update or write new protocols/MOS/SOP
10. Present your results in a synthetic manner based on your rigor analysis
11. Work within a team and develop cross-functional interactions in the context of conducting experiments within the group but also with other teams in the platform.
12. Logistic / orders
13. Must be receptive to instruction and demonstrate aptitude for learning new technologies

Requirements

Diploma’s / Degrees: Bachelor of science degree or equivalent in Biology (Bac +2/3)

Valid Level 2 animal experimentation accreditation for performing in vivo studies in agreement with the French authorities for animals’ welfare is mandatory.

Validated experience working with mouse models in the pharmaceutical industry/academy, biotech companies or CROs (Experience with preclinical mouse models in oncology, immuno-oncology or immunology models will be a plus)

Other skills

Language: Fluency in French, Scientific English

Proficiency with data analysis methods and software

Informatics: Excellent knowledge of the most common desktop applications (Word, Excel, PowerPoint) and scientific software (Flow Cytometry Software, GraphPad Prism)

Excellent team-working skills while autonomous in her/he daily work

Ability to multi-task with a high attention to detail

Excellent oral communication skill for synthetic and concise presentation of generated results