Paris, France – September 16, 2022

Enterome, a clinical stage biopharmaceutical company developing first-in-class immunomodulatory drugs based on its bacterial Mimicry drug discovery platform, today announces that an oral presentation of its Phase 1/2 clinical trial of EO2401 in patients with first progression/recurrence of glioblastoma (ROSALIE trial), will be made at the European Association of Neuro-Oncology (EANO) Meeting 2022 (Vienna, Austria) in the Award Winning Abstracts session on Saturday, September 17 at 16:00 CEST (full details below) by Professor Ahmed Idbaih, Sorbonne University, AP-HP La Pitié-Salpêtrière & Paris Brain Institute (Paris, France) and a clinical investigator in the ROSALIE trial.

EO2401 is Enterome’s first-in-class off-the-shelf OncoMimics™ cancer immunotherapy. It combines three OncoMimics™ peptides that closely mimic IL13Ra2, BIRC5 and FOXM1, which are known driver antigens present on aggressive solid tumors. In addition, EO2401 contains a CD4 helper peptide UCP2. Enterome selected these OncoMimics™ peptides using its Mimicry platform, which applies best-in-class biocomputational tools and bioassays to identify novel therapeutics from its proprietary database of 20+ million bioactive gut microbiome peptides and proteins.

Professor Ahmed Idbaih said, “Immunotherapies have dramatically improved the prognosis of multiple cancers. At EANO we will be presenting our promising results with a new highly innovative immunotherapy, the OncoMimics™-based therapeutic cancer vaccine EO2401 in combination with nivolumab and/or bevacizumab in patients with glioblastoma. We are delighted to have this opportunity to share our findings with the neuro-oncology community at this prestigious meeting.”

 

 Highlights from the EO2401/ ROSALIE Phase 1/2 trial:

• Data published to date confirm that EO2401 in combination with nivolumab +/- bevacizumab is well tolerated with a safety profile consistent with the safety profiles of nivolumab and bevacizumab.
• EO2401 in combination with nivolumab generated strong systemic immune responses through activation of specific effector memory CD8+ T cells, correlating with efficacy.
• Addition of bevacizumab to EO2401 and nivolumab supported longer treatment durations, and an increase of objective response rate (ORR – 55% vs. 10%), disease control rate (DCR – 82% vs. 34%), and progression-free survival (PFS – 5.5 months vs 1.8 months), with 3 of the first 11 patients showing complete remission.

Details on Enterome’s oral presentation at EANO (ROSALIE study)

• Title: A novel microbiome-derived therapeutic vaccine for patients with recurrent glioblastoma: ROSALIE STUDY
• Presenter: Prof Ahmed IDBAIH, France
• Abstract number:   PL02. 1.A
• Session: PL02 Award Winning Abstracts
• Date: Saturday September 17, 2022 at 16:00 CEST

The abstract has been published in the Official Journal of the Society for Neuro-Oncology and can be viewed here.

 

About ROSALIE

ROSALIE (EOGBM1-18, NCT04116658) is a multicenter, open-label, Phase 1/2 trial investigating EO2401 in combination with nivolumab, and in combination with nivolumab/bevacizumab in patients with glioblastoma at first progression/recurrence after surgery and adjuvant radiotherapy/temozolomide. The trial is assessing safety, tolerability, immunogenicity and preliminary efficacy in approximately 80 patients at centers in the US and Europe.

Download the press release (.pdf format)